Selected publications
A selection of research articles and reviews on living myocardial slices, biomimetic culture and related cardiac tissue models.
The references below are a selection from a wider body of research. They include work using MyoDish, earlier research systems and related methods, as well as reviews of the field.
The foundational study is Fischer et al. (Nature Communications, 2019). The full list of citing publications is available on Google Scholar.
Published with MyoDish and missing here? Let us know.
The publications describe specific experimental conditions and configurations; their findings should be assessed in that context.
Selected publications
2026
- PKC-PKD-NFκB signalling induces cardiomyocyte t-tubule loss via a conserved macropinocytic mechanism Martinez-Vilchez A et al. Cardiovascular Research 122:1470–1486 (2026)
- Advances in Living Myocardial Slice Technology for Heart Failure Research Husetić A et al. Current Heart Failure Reports 23:22 (2026)
- Ventricle-Specific Biomechanical Responses to Inotropic and Vasoactive Drugs in Human Myocardial Slices Langmuur SJJ et al. Journal of Cardiovascular Translational Research 19:53 (2026)
- Pharmacological inhibition of myosin reduces the cytotoxic effect of a Lys49 PLA2-like myotoxin on human and rat cardiac muscle Agyapong W et al. Biomedicine & Pharmacotherapy 195:119017 (2026)
- Models of the human heart for biomedical research: Opportunities and challenges Streckfuss-Bömeke K et al. Physiological Reports 14:e70845 (2026)
- Ex-vivo culture of human hypertrophic cardiomyopathy hearts: Functional and metabolic changes during long-term culture Nassar A et al. iScience 29:115308 (2026)
- Transcriptional and functional effects of mavacamten in multiple porcine and human models with hypertrophic cardiomyopathy Kiselev E et al. British Journal of Pharmacology 183:1122–1139 (2026)
2025
- Optimized Conditions for Electrical Tissue Stimulation with Biphasic, Charge-Balanced Impulses Sun Z et al. Bioengineering 12:234 (2025)
- Spatiotemporal dynamics of the cardioimmune niche during lesion repair Chan ASF et al. Nature Cardiovascular Research 4:1550–1572 (2025)
- Dexrazoxane protects against doxorubicin-induced cardiotoxicity in susceptible human living myocardial slices: A proof-of-concept study van der Geest JSA et al. British Journal of Pharmacology 182:4262–4280 (2025)
- Living myocardial slices: walking the path towards standardization van der Geest JSA et al. Cardiovascular Research 121:1011–1023 (2025)
- Increase in mechanical load and pro-fibrotic stimulation leads to fibrotic and hypertrophic remodeling in porcine living myocardial slices Bentele M et al. Scientific Reports 15:41180 (2025)
- Living myocardial slices retain patient-specific features: Insights into etiology and therapeutic history van der Geest JSA et al. JHLT Open 9:100345 (2025)
- Cardioprotective Effects of Semaglutide on Isolated Human Ventricular Myocardium Krammer T et al. European Journal of Heart Failure 27:1315–1325 (2025)
- Acute Biomechanical Effects of Cardiac Contractility Modulation in Living Myocardial Slices from End-Stage Heart Failure Patients Bierhuizen MFA et al. Bioengineering 12:174 (2025)
- Prolonged Hypoxia in Rat Living Myocardial Slices Affects Function, Expression, and Structure Waleczek FJG et al. International Journal of Molecular Sciences 26:218 (2025)
2024
- Biomechanical response of ultrathin slices of hypertrophic cardiomyopathy tissue to myosin modulator mavacamten Amesz JH et al. Biomedicine & Pharmacotherapy 170:116036 (2024)
- Synchronous force and Ca2+ measurements for repeated characterization of excitation-contraction coupling in human myocardium Sun Z et al. Communications Biology 7:220 (2024)
- Effects of electro-mechanical uncouplers, hormonal stimulation and pacing rate on the stability and function of cultured rabbit myocardial slices Baron V et al. Frontiers in Bioengineering and Biotechnology 12:1363538 (2024)
- Ex vivo modelling of cardiac injury identifies ferroptosis-related pathways as a potential therapeutic avenue for translational medicine Abbas N et al. Journal of Molecular and Cellular Cardiology 196:125–140 (2024)
- Inhibition of miR-21: cardioprotective effects in human failing myocardium ex vivo Abbas N et al. European Heart Journal 45:2016–2018 (2024)
- Acute Biomechanical Effects of Empagliflozin on Living Isolated Human Heart Failure Myocardium Amesz JH et al. Cardiovascular Drugs and Therapy 38:659–666 (2024)
2023
- Contractility measurements for cardiotoxicity screening with ventricular myocardial slices of pigs Shi R et al. Cardiovascular Research 119:2469–2481 (2023)
- Ryanodine Receptor Staining Identifies Viable Cardiomyocytes in Human and Rabbit Cardiac Tissue Slices Pfeuffer AKM et al. International Journal of Molecular Sciences 24:13514 (2023)
- Biomimetic cultivation of atrial tissue slices as novel platform for in-vitro atrial arrhythmia studies Amesz JH et al. Scientific Reports 13:3648 (2023)
- Optimized Conditions for the Long-Term Maintenance of Precision-Cut Murine Myocardium in Biomimetic Tissue Culture Cao-Ehlker X et al. Bioengineering 10:171 (2023)
2022
- Chemical and mechanical activation of resident cardiac macrophages in the living myocardial slice ex vivo model Waleczek FJG et al. Basic Research in Cardiology 117:63 (2022)
- Preparation of Human Myocardial Tissue for Long-Term Cultivation Hamers J et al. Journal of Visualized Experiments 184:e63964 (2022)
- Migratory and anti-fibrotic programmes define the regenerative potential of human cardiac progenitors Poch CM et al. Nature Cell Biology 24:659–671 (2022)
- Long-Term Cultivation of Human Atrial Myocardium Klumm MJ et al. Frontiers in Physiology 13:839139 (2022)
- MicroRNA-365 regulates human cardiac action potential duration Esfandyari D et al. Nature Communications 13:220 (2022)
2021
- Sequential Defects in Cardiac Lineage Commitment and Maturation Cause Hypoplastic Left Heart Syndrome Krane M et al. Circulation 144:1409–1428 (2021)
- Progressive stretch enhances growth and maturation of 3D stem-cell-derived myocardium Lu K et al. Theranostics 11:6138–6153 (2021)
2020
- The Degree of t-System Remodeling Predicts Negative Force-Frequency Relationship and Prolonged Relaxation Time in Failing Human Myocardium Abu-Khousa M et al. Frontiers in Physiology 11:182 (2020)
- SARS-CoV-2 infects and induces cytotoxic effects in human cardiomyocytes Bojkova D et al. Cardiovascular Research 116:2207–2215 (2020)
- Somatic gene editing ameliorates skeletal and cardiac muscle failure in pig and human models of Duchenne muscular dystrophy Moretti A et al. Nature Medicine 26:207–214 (2020)
2019
- Long-term functional and structural preservation of precision-cut human myocardium under continuous electromechanical stimulation in vitro Fischer C et al. Nature Communications 10:117 (2019)